Max Perutz Labs
Departments/Research Focus
Christopher Campbell
Research Focus
Chromosome missegregation
Cells prevent aneuploidy largely by correcting misattachments between the chromosomes and the mitotic spindle in mitosis. This error correction is performed primarily by the chromosomal passenger complex (CPC). We have previously determined how different mechanisms of targeting the CPC to areas near its kinetochore targets are essential for this process (Fink et al. 2017, Marsoner et al. 2021). We are currently conducting experiments to identify differences in CPC targeting in meiosis as compared to mitosis.
Aneuploidy
My lab has pioneered methods for generating complex aneuploid karyotypes in yeast both through adaptation experiments and karyotype engineering. We have used these methods to identify previously unknown forces that act to shape the composition of aneuploid karyotypes (Ravichandran et al. 2018, Clarke et al. 2022, Adell et al. 2023, Koller et al. 2025).
Research environment
Our laboratory is located in the Max Perutz Labs at the Vienna Biocenter. Between the core facilities at the institute and those shared with the Vienna Biocenter Core Facilities (VBCF), we have access to an outstanding complement of resources, including the Mac Perutz Labs BioOptics facility, the VBCF Next Generation Sequencing facility, the Max Perutz Labs FACS facility, and the Max Perutz Labs Mass Spectrometry Facility.
Expectations towards postdoctoral fellows in this programme
For the position in the Campbell lab, a successful candidate is expected to have a PhD in a related field, extensive experience with molecular biology techniques, and a solid publication record.
Possible research themes or topics for postdoctoral projects
The main theme for the position in the Campbell lab will be understanding the underlying factors that contribute to aneuploidy patterns. Over 90% of cancers have aneuploidy of at least one chromosome. There are strong patterns in cancer karyotypes for particular chromosomes being frequently gained or lost. These aneuploidies contribute to cancer initiation, progression, and resistance to therapy. However, the mechanism by which these aneuploidies contribute to cancer are largely unknown. We aim to engineer specific aneuploidies de novo and determine their impact on cellular phenotypes.
Weblink for further information:
https://www.maxperutzlabs.ac.at/research/research-groups/campbell
Email: christopher.campbell(at)univie.ac.at
Alexander Dammermann
Research Focus
Centrosomes and cilia perform critical roles in development and tissue homeostasis. Their dysfunction has been linked to tumorigenesis and cancer, as well as developmental disorders including ciliopathies, dwarfism and microcephaly. Research in the Dammermann lab seeks to understand the fundamental and conserved molecular mechanisms underlying centrosome and cilium biogenesis using primarily microscopy-based approaches in C. elegans, but also Drosophila and vertebrate cultured cells. For more details see our lab website, social media and recent publications.
Research environment
The Dammermann lab is located at the Max Perutz Labs, on the campus of the Vienna BioCenter, a hub for biomedical research in Europe with state-of-the-art facilities, including for advanced light and electron microscopy, next generation sequencing and proteomics. As such we are part of a vibrant community, with plenty of scientific and social activities. English is the working language, both in the lab and on campus. Knowledge of German is not required. Collaborations with other labs in Vienna and elsewhere extend the scope of possibilities. Essentially, whatever you want to do we should have the infrastructure and expertise to support it!
Expectations towards postdoctoral fellows in this programme
Projects currently ongoing in the lab seek to study centrosome and cilium biogenesis in a variety of different cellular and developmental contexts. We are seeking highly motivated and collaborative candidates with a background in bioinformatics, cell biology or biochemistry to join our team. Previous experience with C. elegans is not essential. Post-docs are welcome to develop their own research direction. If you have any questions about the lab or would like to discuss potential projects do get in touch!
Weblink for further information:
https://www.maxperutzlabs.ac.at/research/research-groups/dammermann
Email: alex.dammermann(at)univie.ac.at
Sebastian Falk
Research Focus
My research group generally focuses on the mechanistic aspects of RNA metabolism. Specifically, we investigate how small RNA (sRNAs), which function together with Argonaute proteins in RNA interference (RNAi) pathways, contribute to gene expression regulation. We focus on two critical aspects of sRNA biology: how sRNAs are produced (biogenesis) and how they induce gene silencing in the nucleus through the nuclear RNAi pathway. We use a powerful combination of biochemistry and integrative structural biology techniques—such as X-ray crystallography, cryo-EM, and NMR—to develop a mechanistic understanding of these pathways. Additionally, we conduct in vivo studies with engineered mammalian cell lines and C. elegans as model systems for precision biochemistry, complementing our structural analyses.
Research environment
Our group is embedded within the Max Perutz Labs, benefiting from direct access to advanced instrumentation both within the institute and through dedicated core facilities. Available platforms include protein production and characterization, mass spectrometry, high-resolution imaging, and cryo-electron microscopy. The Max Perutz Labs form an integral component of the Vienna BioCenter (VBC), a consortium of four core research institutes characterized by a highly interactive scientific environment. The VBC hosts an active doctoral and postdoctoral community that provides extensive opportunities for scientific training and the development of complementary professional skills. We engage in multiple collaborative projects with research groups both internationally and across the VBC.
Expectations towards postdoctoral fellows in this programme
We seek highly motivated and curious researchers with expertise in protein or RNA biochemistry and structural biology. Prior experience with mammalian cell culture or C. elegans systems is advantageous but not essential. Postdoctoral researchers are expected to operate with a high degree of independence, formulating hypotheses and advancing projects while benefiting from structured support and mentoring. Their responsibilities include data analysis, continuous refinement of experimental strategies, and active participation in the collaborative research environment of the institute and the VBC.
Possible research themes or topics for postdoctoral projects
A) Mechanism of RNA interference in C. elegans: Here we have biochemical and structural biology projects that focus on i) small RNA Biogenesis and ii) nuclear RNA interference / heterochromatin formation
B) Nuclear RNA quality control: in mammalian cells: Here we are looking for a postdoc with experience in structural biololgy to study RNA quality control in the nucleus
Weblink for further information:
https://www.maxperutzlabs.ac.at/research/research-groups/falk
Email: sebastian.falk(at)univie.ac.at
Verena Jantsch-Plunger
Research Focus
The Jantsch lab is working with the animal model Caenorhabditis elegans to understand mechanisms of cell division and chromosome segregation using genetic, cell biological and biochemical approaches. The Jantsch lab has been focusing on processes involved in producing healthy gametes during meiosis. We focus on crucial processes during meiotic prophase, such as chromosome movement, recombination and meiotic entry.
Research environment
The Jantsch lab is hosted by the Dept. of Chromosome Biology at the Max Perutz Labs.
The Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, are part of the Campus Vienna BioCenter (VBC), a hub of biomedical research in Europe with ~3,300 employees from more than 80 countries. We have access to shared facilities either maintained by the Max Perutz Labs or the Vienna BioCenter core facilities (VBCF). In addition to this scientific infrastructure, the VBCF also operate the Child Care Center on campus, which ensures researchers with young children have care close to work.
V. Jantsch leads the special research focus SFB Meiosis, which fosters a highly interactive research community with 9 research groups and 3 associated groups (https://sfbmeiosis.org/). A new postdoc will be part of this community.
Expectations towards postdoctoral fellows in this programme
We expect a postdoc to develop her own project and to step on new scientific ground.
Eventually the work conducted in the Jantsch lab should become the basis for a successful application for a faculty position.
Possible research themes or topics for postdoctoral projects
The postdoc can either work on an existing research question of the lab or develop a novel project with a focus on meiosis and gametogenesis.
Weblink for further information:
https://www.maxperutzlabs.ac.at/research/research-groups/jantsch
Email: verena.jantsch(at)univie.ac.at
Joao Matos
Research Focus
The life cycle of sexually reproducing eukaryotes depends on two specialized chromosome segregation programs: mitosis and meiosis. Whereas mitosis drives cellular proliferation and the stable propagation of the genome, meiosis promotes genetic diversity and the formation of haploid gametes, which combine at fertilization to restore the diploid state. Remarkably, both genome stability and genetic diversity rely on the ability of cells to repair damaged chromosomes through homologous recombination.
We study how cells rewire the DNA repair machinery in order to: (i) promote genetic diversity and haploidisation during meiosis; (ii) prevent genomic instability – and thus cancer – during mitotic proliferation; and, in a newer research line in the group, (iii) understand how meiotic cells “pack” into gametes all components that are necessary to restart life, while also performing the quality control required for gamete rejuvenation.
Our lab has active, open research projects in all of these areas. To tackle these questions, we combine a variety of model systems and approaches, including budding yeast, mouse models, cell culture systems, and biochemistry, allowing us to bridge mechanistic insight with physiological relevance.
Research environment
Our lab offers a dynamic, collaborative environment for postdocs interested in chromosome biology, DNA repair, and meiosis. We are embedded in the Max Perutz Labs at the Vienna BioCenter, a vibrant campus that brings together multiple institutes with complementary strengths in molecular biology, structural biology, cell biology, and genomics. Postdocs benefit from state-of-the-art core facilities (imaging, proteomics, genomics, animal facility), close interactions with expert groups across the campus, and a lively international community of early-career scientists.
Within the lab, we work across model systems (yeast, mouse, tissue culture and biochemistry), foster rigorous and open science, and place strong emphasis on mentoring, career development, and scientific independence. Regular joint seminars, journal clubs, and retreats provide ample opportunities for feedback, networking, and new collaborations.
Expectations towards postdoctoral fellows in this programme
Our lab offers a dynamic, collaborative environment for postdocs interested in chromosome biology, DNA repair, and meiosis. We are embedded in the Max Perutz Labs at the Vienna BioCenter, a vibrant campus that brings together multiple institutes with complementary strengths in molecular biology, structural biology, cell biology, and genomics. Postdocs benefit from state-of-the-art core facilities (imaging, proteomics, genomics, animal facility), close interactions with expert groups across the campus, and a lively international community of early-career scientists.
Within the lab, we work across model systems (yeast, mouse, tissue culture and biochemistry), foster rigorous and open science, and place strong emphasis on mentoring, career development, and scientific independence. Regular joint seminars, journal clubs, and retreats provide ample opportunities for feedback, networking, and new collaborations.
Possible research themes or topics for postdoctoral projects
• Mechanisms of crossover control in meiosis
Dissect how specific nucleases, helicases and ZMM proteins act on defined recombination intermediates to ensure crossover assurance and prevent aberrant joint molecules.
• Synaptonemal complex dynamics and chromosome architecture
Define how SC assembly, maintenance and disassembly are coordinated with recombination and how defects feed back on genome stability and gamete quality.
• DNA repair pathway choice in proliferating cells
Investigate how mitotic cells channel lesions into recombination versus non-recombinogenic repair, and how this balance prevents genome instability and cancer.
• Chromatin and nuclear organization in meiotic DNA repair
Study how chromatin remodelers and nuclear architecture influence the formation, processing and resolution of recombination intermediates.
• Dormancy, storage and reactivation
Probe how gametes or other quiescent cells store key components in a protected state and rewire metabolism and DNA repair upon re-entry into the cell cycle.
Weblink for further information:
https://www.maxperutzlabs.ac.at/research/research-groups/matos
Email: joao.matos(at)univie.ac.at
Jonas Ries
Research Focus
Our aim is to develop super-resolution microscopy techniques to measure the structure and dynamics of proteins in living cells. Specifically, we push Single-molecule localization microscopy to angstrom resolution and use the new MINFLUX technology to directly monitor conformational changes of proteins in living cells. We use these techniques to investigate key questions on clathrin-mediated endocytosis and on motor proteins.
Research environment
We are an interdisciplinary lab with physicists, biologists and computer engineers. Together we push the limits of optical microscopy to address biological questions that previously were out of reach.
Expectations towards postdoctoral fellows in this programme
We are looking for motivated postdocs who like to work in a team and don't shy away from talking to people from other disciplines. If you want to bring your own biological project to be addressed with our technologies, a high degree of independence is expected.
Possible research themes or topics for postdoctoral projects
We are open to applicants with a background in optics, software or biology to either continue existing projects in the lab or to propose own ideas. As our research focus is on super-resolution microscopy, our technologies should play an important role in the proposed project.
Weblink for further information: https://www.maxperutzlabs.ac.at/research/research-groups/ries
Email: jonas.ries(at)univie.ac.at
Peter Schlögelhofer
Research Focus
Meiosis is a specialized, two-step cell division that ensures the reduction of the genome prior to the formation of generative cells. During meiosis, homologous chromosomes are segregated during the first, and sister chromatids during the second division. It is important to note, that during meiosis, genetic information between maternal and paternal chromosomes is mutually exchanged, leading to novel combinations of genetic traits in the following generation.
The Schlögelhofer Lab (https://www.maxperutzlabs.ac.at/research/research-groups/schloegelhofer) investigates molecular determinants of inheritance (in plants and yeast) using cutting edge technologies. We are interested to understand: How is genetic information recombined during meiosis? Which proteins mediate DNA double strand break (DSB) formation, DSB processing and DNA repair during meiosis to ensure recombination of genetic traits? What are the underlying molecular mechanisms?
Research environment
The Schlögelhofer research group is part of the Max Perutz Labs, a joint venture between the University of Vienna and the Medical University of Vienna embedded in the Vienna BioCenter Campus (VBC). The VBC is one of Europe’s biggest life sciences hubs with more than 2,800 employees from about 80 different countries, offering a unique combination of research, education, and companies on a single campus. The Max Perutz Labs and the VBC host a broad spectrum of scientific facilities (https://www.maxperutzlabs.ac.at/research/facilities)( https://www.viennabiocenter.org/vbcf/), including BioOptics, mass spectrometry, plant growth, advanced imaging including CryoEM and next generation sequencing. The Schlögelhofer Lab is well-funded, equipped to perform all modern-day experiments in molecular biology and entertains local and international collaborations to embed co-workers in a supportive network.
Expectations towards postdoctoral fellows in this programme
Post-doctoral co-workers will be embedded in the Schlögelhofer Lab, provided with all research materials and will have access to all mentioned research facilities. They will be personally supported and guided by Prof. Schlögelhofer to develop an attractive research project and to prepare for a future career in academia. The research project will be closely aligned to the research focus of the Schlögelhofer Lab and successful candidates will intellectually and technically strengthen the team and benefit from a stimulating environment and established methodologies.
All research institutes at the VBC consider mentoring an intrinsic part of education and post-docs will have additional mentors (senior faculty) and will be part of a structured mentoring scheme (https://www.maxperutzlabs.ac.at/education/postdoc). Organised activities include leadership training, networking events and different workshops (for instance for career development or for specific technical advances).
Weblink for further information:
https://www.maxperutzlabs.ac.at/research/research-groups/schloegelhofer
Email: peter.schloegelhofer(at)univie.ac.at